Breeding for resistance to the main diseases is very important part of sunflower history in Russia. The list of most important diseases is changed depending on the region and time. Traditionally sunflower breeders pay more attention to broomrape downy mildew and Diaporthe stem canker in Krasnodar region. The aim of our study was to evaluate dynamics for resistance of sunflower lines and hybrids to the most important diseases in a breeding program of All-Russia Research Institute of Oil Crops (VNIIMK) in Krasnodar in order to correct it. Experiments were conducted at the Central Station of VNIIMK from 2000 till 2013. Released prospective and experimental sunflower hybrids and lines of VNIIMK breeding were used as a material. Experimental design was randomized blocks with three replications. Field resistance was evaluated by specialists from the Immunology laboratory of VNIIMK. Results of new experimental sunflower hybrids evaluation for resistance to main diseases are shown. Increasing of some pathogens occurrence is noticed which requires taking more attention to them in the resistance breeding program. These data can be used for breeding program improvement.